Inconsistent embryo selection across polygenic score methods

Shinichi Namba (), Masato Akiyama, Haruka Hamanoue, Kazuto Kato, Minae Kawashima, Itaru Kushima, Koichi Matsuda, Masahiro Nakatochi, Soichi Ogishima, Kyuto Sonehara, Ken Suzuki, Atsushi Takata, Gen Tamiya, Chizu Tanikawa, Kenichi Yamamoto, Natsuko Yamamoto, Norio Ozaki and Yukinori Okada ()
Additional contact information
Shinichi Namba: The University of Tokyo
Masato Akiyama: Kyushu University
Haruka Hamanoue: Yokohama City University Hospital
Kazuto Kato: Osaka University
Minae Kawashima: ROIS-DS
Itaru Kushima: Nagoya University Graduate School of Medicine
Koichi Matsuda: The University of Tokyo
Masahiro Nakatochi: Nagoya University Graduate School of Medicine
Soichi Ogishima: Tohoku University
Kyuto Sonehara: The University of Tokyo
Ken Suzuki: Osaka University
Atsushi Takata: RIKEN Center for Brain Science
Gen Tamiya: Tohoku University Graduate School of Medicine
Chizu Tanikawa: The University of Tokyo
Kenichi Yamamoto: Osaka University
Natsuko Yamamoto: Osaka University
Norio Ozaki: Nagoya University Graduate School of Medicine
Yukinori Okada: The University of Tokyo

Nature Human Behaviour, 2024, vol. 8, issue 12, 2264-2267

Abstract: Private enterprises offer preimplantation genetic testing with polygenic scores to select embryos with ‘desirable’ potential. In silico simulations using biobank resources show that the selected embryo would rely substantially on the choice of polygenic score method and randomness in score construction, which raises ethical concerns.

Date: 2024
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DOI: 10.1038/s41562-024-02019-y

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