An ecotoxicological view on malaria vector control with ivermectin-treated cattle

Andre Patrick Heinrich (), Sié Hermann Pooda, Angélique Porciani, Lamidi Zéla, Alexandra Schinzel, Nicolas Moiroux, Christophe Roberge, Marie-Sophie Martina, Anne-Laure Courjaud, Roch K. Dabiré, Jörg Römbke, Rolf-Alexander Düring and Karine Mouline
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Andre Patrick Heinrich: Justus Liebig University Giessen
Sié Hermann Pooda: Université de Dédougou
Angélique Porciani: Université de Montpellier, CNRS, IRD
Lamidi Zéla: Université de Dédougou
Alexandra Schinzel: Justus Liebig University Giessen
Nicolas Moiroux: Université de Montpellier, CNRS, IRD
Christophe Roberge: Medincell S.A.
Marie-Sophie Martina: Medincell S.A.
Anne-Laure Courjaud: Debiopharm Research and Manufacturing S.A.
Roch K. Dabiré: Institut de Recherche en Sciences de la Santé
Jörg Römbke: RPR GbR
Rolf-Alexander Düring: Justus Liebig University Giessen
Karine Mouline: Université de Montpellier, CNRS, IRD

Nature Sustainability, 2024, vol. 7, issue 6, 724-736

Abstract: Abstract Malaria remains an enduring challenge in sub-Saharan Africa, affecting public health and development. Control measures can include the use of insecticides that target adult Anopheles mosquitoes transmitting the malaria-causing Plasmodium parasite. Such mosquitoes can also bite livestock, allowing vector populations to be maintained at levels that enable parasite transmission. Thus, one way to control the spread of malaria includes the use of endectocide-treated livestock which renders the blood of cattle toxic to such mosquito populations. Here we present an ecotoxicological perspective on malaria vector control, using cattle treated with the endectocide ivermectin to target zoophagic and opportunistic Anopheles coluzzii mosquitoes. Our study employs an innovative, long-acting injectable ivermectin formulation with over 6 months of sustained mosquitocidal activity. Robust vector population modelling underscores its promising field effectiveness. Environmental implications (soil sorption and dissipation) of excreted ivermectin and potential ecotoxicological risks to non-target dung organisms in West Africa are discussed, in addition to actionable, locally inspired risk mitigation measures to protect sub-Saharan soils and agroecosystems from chemical pollution. We highlight how ecotoxicology and environmental chemistry improve livestock-based vector control with ivermectin for effective and more sustainable malaria management.

Date: 2024
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DOI: 10.1038/s41893-024-01332-8

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