Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss

Kurt A. Gust, Mitchell S. Wilbanks, Zachary A. Collier, Lyle D. Burgoon and Edward J. Perkins
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Kurt A. Gust: U.S. Army Engineer Research and Development Center
Mitchell S. Wilbanks: U.S. Army Engineer Research and Development Center
Zachary A. Collier: U.S. Army Engineer Research and Development Center
Lyle D. Burgoon: U.S. Army Engineer Research and Development Center
Edward J. Perkins: U.S. Army Engineer Research and Development Center

No 10, OECD Series on Adverse Outcome Pathways from OECD Publishing

Abstract: The present AOP describes antagonistic chemical binding to the peroxisome proliferator-activated receptor α (PPARα), resulting in preferential binding a co-repressor to the overall PPARα signalling complex causing a chain of events that includes: antagonism of PPARα nuclear signalling, decreased transcriptional expression of PPARα-regulated genes that support energy metabolism, inhibited metabolic energy production (decreased fatty acid beta oxidation and ketogenesis), and increase in catabolism of muscle protein, culminating with starvation-like weight loss. The AOP is likely to be synergised during fasting, starvation or malnutrition events. The adverse outcome of this AOP is body-weight loss, which within the context of dynamic energy budget theory, decreases energy allocations to organismal maturation and reproduction and has been demonstrated to negatively affect ecological fitness.

Date: 2019-07-30
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