Pre-emptive pharmacogenetic testing in Italy: a review of evidence and multidisciplinary consensus on key priorities for implementation

Angelica Valz Gris, Antonio Cristiano, Francesco Di Berardino, Erika Giacobini, Vittoria Tricomi, Angelo Pezzullo, Erika Cecchin, Valeria Conti, Amelia Filippelli and Fiorella Gurrieri
Additional contact information
Angelica Valz Gris: Università Cattolica del Sacro Cuore, Rome, Italy

No 7vtxp_v1, SocArXiv from Center for Open Science

Abstract: Pre-emptive pharmacogenetic (PGx) testing involves identifying genetic variants associated with drug response prior to prescribing medication, with the aim of guiding potential future drug selection or dosing to reduce adverse drug reactions and improve treatment outcomes. Despite decreasing costs and growing feasibility of multi-gene panels, implementation pre-emptive pharmacogenetic testing strategies remains limited across Europe. This study explores the potential impact and barriers to implementation in Italy, combining a review of current evidence with multistage consultations with Italian experts in related fields (pharmacology, laboratory medicine, genetics, clinical care, and public health). Our analysis supports the clinical utility, economic sustainability, and feasibility of pre-emptive PGx testing. However, key barriers persist, including limited real-world data, unclear reimbursement mechanisms, insufficient laboratory and IT infrastructure, poor clinician training, and patient concerns related to privacy and data protection. To address these challenges, we propose strategic actions across six areas: regulatory alignment, research investment, professional training and result interpretation, public awareness and consent, laboratory infrastructure, and IT systems and data governance.

Date: 2025-08-28
New Economics Papers: this item is included in nep-eur and nep-hea
References: Add references at CitEc
Citations:

Downloads: (external link)
https://osf.io/download/68ad82b807954dbbeabcbfb4/

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:osf:socarx:7vtxp_v1

DOI: 10.31219/osf.io/7vtxp_v1

Access Statistics for this paper

More papers in SocArXiv from Center for Open Science
Bibliographic data for series maintained by OSF ().