Chronotopic maps in human supplementary motor area

Foteini Protopapa, Masamichi J Hayashi, Shrikanth Kulashekhar, Wietske van der Zwaag, Giovanni Battistella, Micah M Murray, Ryota Kanai and Domenica Bueti

PLOS Biology, 2019, vol. 17, issue 3, 1-34

Abstract: Time is a fundamental dimension of everyday experiences. We can unmistakably sense its passage and adjust our behavior accordingly. Despite its ubiquity, the neuronal mechanisms underlying the capacity to perceive time remains unclear. Here, in two experiments using ultrahigh-field 7-Tesla (7T) functional magnetic resonance imaging (fMRI), we show that in the medial premotor cortex (supplementary motor area [SMA]) of the human brain, neural units tuned to different durations are orderly mapped in contiguous portions of the cortical surface so as to form chronomaps. The response of each portion in a chronomap is enhanced by neighboring durations and suppressed by nonpreferred durations represented in distant portions of the map. These findings suggest duration-sensitive tuning as a possible neural mechanism underlying the recognition of time and demonstrate, for the first time, that the representation of an abstract feature such as time can be instantiated by a topographical arrangement of duration-sensitive neural populations.Author summary: Sensing the passage of time is a common experience of our everyday life activity. Even without a watch, we can, for example, tell whether the bus we are waiting for is late. The neuronal mechanism that enables us to sense the passage of time is largely unknown. Here, we asked healthy human volunteers to discriminate between visual events of varying durations while we measured brain activity via functional magnetic resonance imaging (fMRI). The results show that distinct portions of the supplementary motor area (SMA)—a region of the cerebral cortex important for both motor preparation and time perception—respond preferentially to different durations. The portions of the SMA responding to similar durations are in close spatial proximity on the cortex, and their response is greater for preferred and neighboring durations and suppressed for distant ones. The spatial arrangement of duration-selective portions of the SMA could be the mechanism that enables us to efficiently sense that a certain duration has elapsed.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pbio00:3000026

DOI: 10.1371/journal.pbio.3000026

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