Assembly of Nsp1 Nucleoporins Provides Insight into Nuclear Pore Complex Gating

Ramya Gamini, Wei Han, John E Stone and Klaus Schulten

PLOS Computational Biology, 2014, vol. 10, issue 3, 1-14

Abstract: Nuclear pore complexes (NPCs) form gateways for material transfer across the nuclear envelope of eukaryotic cells. Disordered proteins, rich in phenylalanine-glycine repeat motifs (FG-nups), form the central transport channel. Understanding how nups are arranged in the interior of the NPC may explain how NPC functions as a selectivity filter for transport of large molecules and a sieve-like filter for diffusion of small molecules (

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1003488

DOI: 10.1371/journal.pcbi.1003488

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