Eight quick tips for biologically and medically informed machine learning

Luca Oneto and Davide Chicco

PLOS Computational Biology, 2025, vol. 21, issue 1, 1-13

Abstract: Machine learning has become a powerful tool for computational analysis in the biomedical sciences, with its effectiveness significantly enhanced by integrating domain-specific knowledge. This integration has give rise to informed machine learning, in contrast to studies that lack domain knowledge and treat all variables equally (uninformed machine learning). While the application of informed machine learning to bioinformatics and health informatics datasets has become more seamless, the likelihood of errors has also increased. To address this drawback, we present eight guidelines outlining best practices for employing informed machine learning methods in biomedical sciences. These quick tips offer recommendations on various aspects of informed machine learning analysis, aiming to assist researchers in generating more robust, explainable, and dependable results. Even if we originally crafted these eight simple suggestions for novices, we believe they are deemed relevant for expert computational researchers as well.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1012711

DOI: 10.1371/journal.pcbi.1012711

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