Travel-Related Venous Thrombosis: Results from a Large Population-Based Case Control Study (MEGA Study)

Suzanne C Cannegieter, Carine J M Doggen, Hans C van Houwelingen and Frits R Rosendaal

PLOS Medicine, 2006, vol. 3, issue 8, 1-8

Abstract: Background: Recent studies have indicated an increased risk of venous thrombosis after air travel. Nevertheless, questions on the magnitude of risk, the underlying mechanism, and modifying factors remain unanswered. Methods and Findings: We studied the effect of various modes and duration of travel on the risk of venous thrombosis in a large ongoing case-control study on risk factors for venous thrombosis in an unselected population (MEGA study). We also assessed the combined effect of travel and prothrombotic mutations, body mass index, height, and oral contraceptive use. Conclusions: The risk of venous thrombosis after travel is moderately increased for all modes of travel. Subgroups exist in which the risk is highly increased. In a large case-control study of travelers, the risk of venous thrombosis was increased 3-fold with a similar risk for flying or travelling by car, bus, or train. :

Date: 2006
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:0030307

DOI: 10.1371/journal.pmed.0030307

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