Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study

Kaura, Amit; Hartley, Adam; Panoulas, Vasileios; Glampson, Ben; Shah, Anoop S V; Davies, Jim; Mulla, Abdulrahim; Woods, Kerrie; Omigie, Joe; Shah, Anoop D; Thursz, Mark R; Elliott, Paul; Hemmingway, Harry; Williams, Bryan; Asselbergs, Folkert W; O’Sullivan, Michael; Lord, Graham M; Trickey, Adam; Sterne, Jonathan AC; Haskard, Dorian O; Melikian, Narbeh; Francis, Darrel P; Koenig, Wolfgang; Shah, Ajay M; Kharbanda, Rajesh; Perera, Divaka; Patel, Riyaz S; Channon, Keith M; Mayet, Jamil; Khamis, Ramzi

Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study

Amit Kaura, Adam Hartley, Vasileios Panoulas, Ben Glampson, Anoop S V Shah, Jim Davies, Abdulrahim Mulla, Kerrie Woods, Joe Omigie, Anoop D Shah, Mark R Thursz, Paul Elliott, Harry Hemmingway, Bryan Williams, Folkert W Asselbergs, Michael O’Sullivan, Graham M Lord, Adam Trickey, Jonathan AC Sterne, Dorian O Haskard, Narbeh Melikian, Darrel P Francis, Wolfgang Koenig, Ajay M Shah, Rajesh Kharbanda, Divaka Perera, Riyaz S Patel, Keith M Channon, Jamil Mayet and Ramzi Khamis

PLOS Medicine, 2022, vol. 19, issue 2, 1-17

Abstract: Background: There is limited evidence on the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for selecting patients for advanced cardiovascular (CV) therapies in the modern era. The prognostic value of mildly elevated hsCRP beyond troponin in a large real-world cohort of unselected patients presenting with suspected acute coronary syndrome (ACS) is unknown. We evaluated whether a mildly elevated hsCRP (up to 15 mg/L) was associated with mortality risk, beyond troponin level, in patients with suspected ACS. Methods and findings: We conducted a retrospective cohort study based on the National Institute for Health Research Health Informatics Collaborative data of 257,948 patients with suspected ACS who had a troponin measured at 5 cardiac centres in the United Kingdom between 2010 and 2017. Patients were divided into 4 hsCRP groups (

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:1003911

DOI: 10.1371/journal.pmed.1003911

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