National adaptation and implementation of WHO Model List of Essential Medicines: A qualitative evidence synthesis

Elizabeth F Peacocke, Sonja L Myhre, Hakan Safaralilo Foss and Unni Gopinathan

PLOS Medicine, 2022, vol. 19, issue 3, 1-23

Abstract: Background: The World Health Organization Model List of Essential Medicines (WHO EML) has played a critical role in guiding the country-level selection and financing of medicines for more than 4 decades. It continues to be a relevant evidence-based policy that can support universal health coverage (UHC) and access to essential medicines. The objective of this review was to identify factors affecting adaptation and implementation of WHO EML at the national level. Methods and findings: We conducted a qualitative evidence synthesis by searching 10 databases (including CINAHL, Embase, Ovid MEDLINE, Scopus, and Web of Science) through October 2021. Primary qualitative studies focused on country-level implementation of WHO EML were included. The qualitative findings were populated in the Specialist Unit for Review Evidence (SURE) checklist, and key themes were identified through an iterative process. We appraised the papers using the Critical Appraisal Skills Programme (CASP) tool and assessed our confidence in the findings using the Grading of Recommendations Assessment, Development and Evaluation working group-Confidence in Evidence from Reviews of Qualitative research (GRADE-CERQual). We screened 1,567 unique citations, reviewed 183 full texts, and included 23 studies, from 30 settings. Non-English studies and experiences and perceptions of stakeholders published in gray literature were not collected. Conclusions: This qualitative evidence synthesis underscores the complexity and interdependencies inherent to implementation of WHO EML. To maximize the value of NMLs, greater investments should be made in processes and institutions that are needed to support various stages of the implementation pathway from global norms to adjusting prescribed behavior. Moreover, further research on linkages between NMLs, procurement, and the availability of medicines will provide additional insight into optimal NML implementation. Protocol registry: PROSPERO CRD42018104112 Elizabeth F Peacocke and colleagues review factors associated with adaptation and implementation of the WHO model list of essential medicines at the national level.Why was this study done: What did the researchers do and find: What do these findings mean:

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pmed00:1003944

DOI: 10.1371/journal.pmed.1003944

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