Nifurtimox plus Eflornithine for Late-Stage Sleeping Sickness in Uganda: A Case Series

Francesco Checchi, Patrice Piola, Harriet Ayikoru, Florence Thomas, Dominique Legros and Gerardo Priotto

PLOS Neglected Tropical Diseases, 2007, vol. 1, issue 2, 1-6

Abstract: Background: We report efficacy and safety outcomes from a prospective case series of 31 late-stage T.b. gambiense sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+E) in Yumbe, northwest Uganda in 2002–2003, following on a previously reported terminated trial in nearby Omugo, in which 17 patients received the combination under the same conditions. Methodology/Principal findings: Eligible sequential late-stage patients received 400 mg/Kg/day eflornithine (Ornidyl, Sanofi-Aventis) for seven days plus 15 mg/Kg/day (20 mg for children

Date: 2007
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0000064

DOI: 10.1371/journal.pntd.0000064

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