Importance of Coverage and Endemicity on the Return of Infectious Trachoma after a Single Mass Antibiotic Distribution

Takele Lakew, Wondu Alemayehu, Muluken Melese, Elizabeth Yi, Jenafir I House, Kevin C Hong, Zhaoxia Zhou, Kathryn J Ray, Travis C Porco, Bruce D Gaynor, Thomas M Lietman and Jeremy D Keenan

PLOS Neglected Tropical Diseases, 2009, vol. 3, issue 8, 1-5

Abstract: Background: As part of the SAFE strategy, mass antibiotic treatments are useful in controlling the ocular strains of chlamydia that cause trachoma. The World Health Organization recommends treating at least 80% of individuals per community. However, the role of antibiotic coverage for trachoma control has been poorly characterized. Methodology/Principal Findings: In a collection of cluster-randomized clinical trials, mass oral azithromycin was administered to 40 villages in Ethiopia. The village prevalence of ocular chlamydia was determined before treatment, and at two and six months post-treatment. The mean prevalence of ocular chlamydia was 48.9% (95% CI 42.8 to 55.0%) before mass treatments, decreased to 5.4% (95% CI 3.9 to 7.0%) at two months after treatments (p

Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0000507

DOI: 10.1371/journal.pntd.0000507

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