Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children: A Case-Control Study

Raaj S Mehta, Alejandro Rodriguez, Martha Chico, Irene Guadalupe, Nely Broncano, Carlos Sandoval, Fernanda Tupiza, Edward Mitre and Philip J Cooper

PLOS Neglected Tropical Diseases, 2012, vol. 6, issue 7, 1-6

Abstract: Background: Children of mothers infected with soil-transmitted helminths (STH) may have an increased susceptibility to STH infection. Methods and Findings: We did a case-control study nested in a birth cohort in Ecuador. Data from 1,004 children aged 7 months to 3 years were analyzed. Cases were defined as children with Ascaris lumbricoides and/or Trichuris trichiura, controls without. Exposure was defined as maternal infection with A. lumbricoides and/or T. trichiura, detected during the third trimester of pregnancy. The analysis was restricted to households with a documented infection to control for infection risk. Children of mothers with STH infections had a greater risk of infection compared to children of uninfected mothers (adjusted OR 2.61, 95% CI: 1.88–3.63, p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0001753

DOI: 10.1371/journal.pntd.0001753

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