Efficacy and Safety of Praziquantel in Preschool-Aged Children in an Area Co-Endemic for Schistosoma mansoni and S. haematobium

Jean T Coulibaly, Yve K N'Gbesso, Stefanie Knopp, Jennifer Keiser, Eliézer K N'Goran and Jürg Utzinger

PLOS Neglected Tropical Diseases, 2012, vol. 6, issue 12, 1-9

Abstract: Background: In sub-Saharan Africa the recommended strategy to control schistosomiasis is preventive chemotherapy. Emphasis is placed on school-aged children, but in high endemicity areas, preschool-aged children are also at risk, and hence might need treatment with praziquantel. Since a pediatric formulation (e.g., syrup) is not available outside of Egypt, crushed praziquantel tablets are used, but the efficacy and safety of this treatment regimen is insufficiently studied. Methodology: We assessed the efficacy and safety of crushed praziquantel tablets among preschool-aged children (

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0001917

DOI: 10.1371/journal.pntd.0001917

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