Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy

Gabrielle Debacq, Luz M Moyano, Héctor H Garcia, Farid Boumediene, Benoit Marin, Edgard B Ngoungou and Pierre-Marie Preux

PLOS Neglected Tropical Diseases, 2017, vol. 11, issue 3, 1-17

Abstract: Background: We reviewed studies that analyzed cysticercosis (CC), neurocysticercosis (NCC) and epilepsy across Latin America, Asia and Sub-Saharan Africa, to estimate the odds ratio and etiologic fraction of epilepsy due to CC in tropical regions. Methodology: We conducted a systematic review of the literature on cysticercosis and epilepsy in the tropics, collecting data from case-control and cross-sectional studies. Exposure criteria for CC included one or more of the following: serum ELISA or EITB positivity, presence of subcutaneous cysts (both not verified and unverified by histology), histology consistent with calcified cysts, and brain CT scan consistent with NCC. A common odds-ratio was then estimated using meta-analysis. Principal findings: 37 studies from 23 countries were included (n = 24,646 subjects, 14,934 with epilepsy and 9,712 without epilepsy). Of these, 29 were case-control (14 matched). The association between CC and epilepsy was significant in 19 scientific articles. Odds ratios ranged from 0.2 to 25.4 (a posteriori power 4.5–100%) and the common odds ratio was 2.7 (95% CI 2.1–3.6, p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0005153

DOI: 10.1371/journal.pntd.0005153

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