Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol

Kristjana Hrönn Ásbjörnsdóttir, Sitara S Rao Ajjampur, Roy M Anderson, Robin Bailey, Iain Gardiner, Katherine E Halliday, Moudachirou Ibikounle, Khumbo Kalua, Gagandeep Kang, D Timothy J Littlewood, Adrian J F Luty, Arianna Rubin Means, William Oswald, Rachel L Pullan, Rajiv Sarkar, Fabian Schär, Adam Szpiro, James E Truscott, Marleen Werkman, Elodie Yard, Judd L Walson and The DeWorm3 Trials Team

PLOS Neglected Tropical Diseases, 2018, vol. 12, issue 1, 1-16

Abstract: Trial registration: ClinicalTrials.gov NCT03014167 Author summary: Soil-transmitted helminths (STH) affect 1.45 billion people worldwide, and high intensity infections are associated with anemia, undernutrition and impaired cognition, particularly among children. Mathematical models suggest it may be possible to interrupt the transmission of STH in a community by expanding mass drug administration (MDA) from targeted high-risk groups (primarily school-aged children and women of child-bearing age) to all community members with high coverage. The DeWorm3 Project will test the feasibility of this approach to interrupting the transmission of STH using a series of cluster randomized trials in Benin, India and Malawi. Each study area (population ≥80,000) will be divided into 40 clusters and randomized to community-wide or standard-of-care targeted MDA for three years. Two years following the final round of MDA, prevalence of STH will be compared between arms and transmission interruption assessed in each cluster. The DeWorm3 trials will provide stakeholders with information regarding the potential to switch from STH control to a more ambitious and sustainable strategy.

Date: 2018
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006166 (text/html)
https://journals.plos.org/plosntds/article/file?id ... 06166&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0006166

DOI: 10.1371/journal.pntd.0006166

Access Statistics for this article

More articles in PLOS Neglected Tropical Diseases from Public Library of Science
Bibliographic data for series maintained by plosntds ().