Long term outcomes and prognostics of visceral leishmaniasis in HIV infected patients with use of pentamidine as secondary prophylaxis based on CD4 level: a prospective cohort study in Ethiopia

Ermias Diro, Tansy Edwards, Koert Ritmeijer, Helina Fikre, Charles Abongomera, Aderajew Kibret, Clélia Bardonneau, Peninah Soipei, Brian Mutinda, Raymond Omollo, Johan van Griensven, Eduard E Zijlstra, Monique Wasunna, Fabiana Alves, Jorge Alvar, Asrat Hailu, Neal Alexander and Séverine Blesson

PLOS Neglected Tropical Diseases, 2019, vol. 13, issue 2, 1-17

Abstract: Background: The long-term treatment outcome of visceral leishmaniasis (VL) patients with HIV co-infection is complicated by a high rate of relapse, especially when the CD4 count is low. Although use of secondary prophylaxis is recommended, it is not routinely practiced and data on its effectiveness and safety are limited. Methods: A prospective cohort study was conducted in Northwest Ethiopia from August 2014 to August 2017 (NCT02011958). HIV-VL patients were followed for up to 12 months. Patients with CD4 cell counts below 200/μL at the end of VL treatment received pentamidine prophylaxis starting one month after parasitological cure, while those with CD4 count ≥200 cells/μL were followed without secondary prophylaxis. Compliance, safety and relapse-free survival, using Kaplan-Meier analysis methods to account for variable time at risk, were summarised. Risk factors for relapse or death were analysed. Results: Fifty-four HIV patients were followed. The probability of relapse-free survival at one year was 50% (95% confidence interval [CI]: 35–63%): 53% (30–71%) in 22 patients with CD4 ≥200 cells/μL without pentamidine prophylaxis and 46% (26–63%) in 29 with CD4

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0007132

DOI: 10.1371/journal.pntd.0007132

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