Assessment of control strategies against Clonorchis sinensis infection based on a multi-group dynamic transmission model

Xiao-Hong Huang, Men-Bao Qian, Guang-Hu Zhu, Yue-Yi Fang, Yuan-Tao Hao and Ying-Si Lai

PLOS Neglected Tropical Diseases, 2020, vol. 14, issue 3, 1-23

Abstract: Clonorchiasis is one of the most important food-borne trematodiases affecting millions of people. Strategies were recommended by different organizations and control programmes were implemented but mostly in short-time periods. It’s important to assess the long-term benefits and sustainability of possible control strategies on morbidity control of the disease. We developed a multi-group transmission model to describe the dynamics of C. sinensis transmission among different groups of people with different raw-fish-consumption behaviors, based on which, a full model with interventions was proposed and three common control measures (i.e., preventive chemotherapy, information, education, and communication (IEC) and environmental modification) and their possible combinations were considered. Under a typical setting of C. sinensis transmission, we simulated interventions according to different strategies and with a series of values of intervention parameters. We found that combinations of measures were much beneficial than those singly applied; higher coverages of measures had better effects; and strategies targeted on whole population performed better than that on at-risk population with raw-fish-consumption behaviors. The strategy recommended by the government of Guangdong Province, China shows good and sustainable effects, under which, the infection control (with human prevalence

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0008152

DOI: 10.1371/journal.pntd.0008152

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