Safety and efficacy of co-administered diethylcarbamazine, albendazole and ivermectin during mass drug administration for lymphatic filariasis in Haiti: Results from a two-armed, open-label, cluster-randomized, community study

Christine L Dubray, Anita D Sircar, Valery Madsen Beau de Rochars, Joshua Bogus, Abdel N Direny, Jean Romuald Ernest, Carl R Fayette, Charles W Goss, Marisa Hast, Kobie O’Brian, Guy Emmanuel Pavilus, Daniel Frantz Sabin, Ryan E Wiegand, Gary J Weil and Jean Frantz Lemoine

PLOS Neglected Tropical Diseases, 2020, vol. 14, issue 6, 1-21

Abstract: In Haiti, 22 communes still require mass drug administration (MDA) to eliminate lymphatic filariasis (LF) as a public health problem. Several clinical trials have shown that a single oral dose of ivermectin (IVM), diethylcarbamazine (DEC) and albendazole (ALB) (IDA) is more effective than DEC plus ALB (DA) for clearing Wuchereria bancrofti microfilariae (Mf). We performed a cluster-randomized community study to compare the safety and efficacy of IDA and DA in an LF-endemic area in northern Haiti. Ten localities were randomized to receive either DA or IDA. Participants were monitored for adverse events (AE), parasite antigenemia, and microfilaremia. Antigen-positive participants were retested one year after MDA to assess treatment efficacy. Fewer participants (11.0%, 321/2917) experienced at least one AE after IDA compared to DA (17.3%, 491/2844, P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0008298

DOI: 10.1371/journal.pntd.0008298

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