Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial

Rajabu Hussein Mnkugwe, Omary Minzi, Safari Kinung’hi, Appolinary Kamuhabwa and Eleni Aklillu

PLOS Neglected Tropical Diseases, 2020, vol. 14, issue 9, 1-18

Abstract: Background: Despite the reported success in reducing morbidity, praziquantel alone is insufficient for the control and elimination of schistosomiasis, partly due to its poor efficacy against the juvenile worms. Artemisinin derivatives are effective against juvenile worms but are less effective against adult worms. We compared the safety and efficacy of praziquantel and Dihydroartemisinin-piperaquine combination against the standard praziquantel alone for treatment of intestinal schistosomiasis. Methods: In this randomized, open-label, non-inferiority trial, 639 Schistosoma mansoni infected children were enrolled and randomized to receive either praziquantel alone or praziquantel plus Dihydroartemisinin-piperaquine combination. Two stool samples were collected on consecutive days at baseline, 3 and 8 weeks post-treatment and analyzed using thick smear Kato Katz method. Efficacy was assessed by cure and egg reduction rates at 3 and 8 weeks post-treatment. Adverse events were assessed within four hours of drugs intake. The primary outcome was cure rates at 8 weeks of post-treatment. Secondary outcomes were egg reduction rates at 8 weeks of post-treatment and treatment-associated adverse events. Results: At 3 weeks of post-treatment, cure rates were 88.3% (263/298, 95% CI = 84.1%– 91.4%) and 81.2% (277/341, 95% CI = 76.7%– 85.0%) for the combination therapy and praziquantel alone, respectively (p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pntd00:0008619

DOI: 10.1371/journal.pntd.0008619

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