Strong Association between Two Polymorphisms on 15q25.1 and Lung Cancer Risk: A Meta-Analysis

Mingliang Gu, Xiaoqun Dong, Xuezhi Zhang, Xumin Wang, Yue Qi, Jun Yu and Wenquan Niu

PLOS ONE, 2012, vol. 7, issue 6, 1-8

Abstract: Background: The association between polymorphisms on 15q25.1 and lung cancer has been widely evaluated; however, the studies have yielded contradictory results. We sought to investigate this inconsistency by performing a comprehensive meta-analysis on two polymorphisms (CHRNA3 gene: rs1051730 and AGPHD1 gene: rs8034191) on 15q25.1. Methods: Data were extracted from 15 and 14 studies on polymorphisms rs1051730 and rs8034191 involving 12301/14000 and 14075/12873 lung cancer cases/controls, respectively. The random-effects model was applied, addressing heterogeneity and publication bias. Results: The two polymorphisms followed Hardy-Weinberg equilibrium for all studies (P>0.05). For rs1051730-G/A, carriers of A allele had a 36% increased risk for lung cancer (95% confidence interval [CI]: 1.27–1.46; P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0037970

DOI: 10.1371/journal.pone.0037970

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