Circulating Levels of Adiponectin, Leptin, Fetuin-A and Retinol-Binding Protein in Patients with Tuberculosis: Markers of Metabolism and Inflammation

Naoto Keicho, Ikumi Matsushita, Takahiro Tanaka, Takuro Shimbo, Nguyen Thi Le Hang, Shinsaku Sakurada, Nobuyuki Kobayashi, Minako Hijikata, Pham Huu Thuong and Luu Thi Lien

PLOS ONE, 2012, vol. 7, issue 6, 1-8

Abstract: Background: Wasting is known as a prominent feature of tuberculosis (TB). To monitor the disease state, markers of metabolism and inflammation are potentially useful. We thus analyzed two major adipokines, adiponectin and leptin, and two other metabolic markers, fetuin-A and retinol-binding protein 4 (RBP4). Methods: The plasma levels of these markers were measured using enzyme-linked immunosorbent assays in 84 apparently healthy individuals ( = no-symptom group) and 46 patients with active pulmonary TB around the time of treatment, including at the midpoint evaluation ( = active-disease group) and compared them with body mass index (BMI), C-reactive protein (CRP), chest radiographs and TB-antigen specific response by interferon-γ release assay (IGRA). Results: In the no-symptom group, adiponectin and leptin showed negative and positive correlation with BMI respectively. In the active-disease group, at the time of diagnosis, leptin, fetuin-A and RBP4 levels were lower than in the no-symptom group [adjusted means 2.01 versus 4.50 ng/ml, P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0038703

DOI: 10.1371/journal.pone.0038703

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