Outcomes of Sustained-Release Formulation of Valproate and Topiramate Monotherapy in Patients with Epilepsy: A Multi-Centre, Cohort Study

Yida Hu, Xishun Huang, Dinglie Shen, Meiping Ding, Hongbin Sun, Bin Peng, Xiangshu Hu, Hua Li, Kebin Zeng, Zhiqin Xi, Ying Zhang, Qingqing Cao, Jing Liu, Yan Zhou, Mengjiao Wu, Yaodong Lu, Guojun Chen and Xuefeng Wang

PLOS ONE, 2012, vol. 7, issue 12, 1-10

Abstract: Background: New-generation antiepileptic drugs (AEDs) tend to replace traditional AEDs as the first-line choice for epilepsy. However, whether this change results in better outcome, especially in China, remains unknown. Methodology/Principal Findings: Two broad spectrum AEDs, the traditional drug of sustained-release formulation of valproate (SRVPA) and the new-generation drug of topiramate, were compared in patients with epilepsy as monotherapy in this multi-centre, observational cohort study from 2000 to 2011. The primary outcome was time to treatment failure. The secondary outcomes included time to first seizure, time to 12-month remission, and time to 24-month remission. Drug tolerability was assessed. Cox proportional hazard models (95% confidence interval [CI]) were used to analyse the relative risks expressed as hazard ratios (HR). Conclusions: The SRVPA is more suitable than topiramate for Chinese epileptic patients, and our results support the viewpoint that traditional AEDs should be the first-line choice for epilepsy rather than new-generation AEDs.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0047982

DOI: 10.1371/journal.pone.0047982

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