Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14

Ana Eugenia Rodríguez, Jose Ángel Hernández, Rocío Benito, Norma C Gutiérrez, Juan Luis García, María Hernández-Sánchez, Alberto Risueño, M Eugenia Sarasquete, Encarna Fermiñán, Rosa Fisac, Alfonso García de Coca, Guillermo Martín-Núñez, Natalia de las Heras, Isabel Recio, Oliver Gutiérrez, Javier De Las Rivas, Marcos González and Jesús M Hernández-Rivas

PLOS ONE, 2012, vol. 7, issue 11, 1-13

Abstract: Background: Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods:: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Results: Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0048485

DOI: 10.1371/journal.pone.0048485

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