Hematopoietically-Expressed Homeobox Gene Three Widely-Evaluated Polymorphisms and Risk for Diabetes: A Meta-Analysis

Xiaobo Li, Yuqiong Li, Bei Song, Shujie Guo, Shaoli Chu, Nan Jia and Wenquan Niu

PLOS ONE, 2012, vol. 7, issue 11, 1-10

Abstract: Background: The hematopoietically-expressed homeobox (HHEX) gene is identified as a promising candidate for type 2 diabetes by genome-wide association studies, triggering plenty of subsequent replications; however, the results are conflicting. We therefore conducted a meta-analysis of three widely-evaluated polymorphisms in HHEX gene and diabetes risk. Methodology/Principal Findings: A random-effects model was adopted irrespective of heterogeneity. Data and study quality were assessed in duplicate. There were 49 studies (cases/controls: 57931/74658) for rs1111875, 18 studies (18227/30366) for rs5015480 and 26 studies (25725/30579) for rs7923837, respectively. Overall analyses indicated that rs1111875-C allele (odds ratio [OR] = 1.16; 95% confidence interval [CI]: 1.13–1.2; P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0049917

DOI: 10.1371/journal.pone.0049917

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