Cost-Effectiveness of Pre-Exposure Prophylaxis (PrEP) in Preventing HIV-1 Infections in Rural Zambia: A Modeling Study

Brooke E Nichols, Charles A B Boucher, Janneke H van Dijk, Phil E Thuma, Jan L Nouwen, Rob Baltussen, Janneke van de Wijgert, Peter M A Sloot and David A M C van de Vijver

PLOS ONE, 2013, vol. 8, issue 3, 1-10

Abstract: Background: Pre-exposure prophylaxis (PrEP) with tenofovir and emtricitabine effectively prevents new HIV infections. The optimal scenario for implementing PrEP where most infections are averted at the lowest cost is unknown. We determined the impact of different PrEP strategies on averting new infections, prevalence, drug resistance and cost-effectiveness in Macha, a rural setting in Zambia. Methods: A deterministic mathematical model of HIV transmission was constructed using data from the Macha epidemic (antenatal prevalence 7.7%). Antiretroviral therapy is started at CD4

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0059549

DOI: 10.1371/journal.pone.0059549

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