Hyperuricemia Is an Independent Risk Factor for New Onset Micro-Albuminuria in a Middle-Aged and Elderly Population: A Prospective Cohort Study in Taiwan

Hung-Yu Chang, Pei-Hsien Lee, Chen-Chou Lei, Chun-Wu Tung, Yung-Chien Hsu, Tung-Jung Huang, Long-chuan Lu and Chun-Liang Lin

PLOS ONE, 2013, vol. 8, issue 4, 1-7

Abstract: Background: Hyperuricemia is now regarded as a risk factor for cardiovascular disease. Micro-albuminuria is associated with increased risk for cardiovascular disease and chronic kidney disease. We hypothesized that elevated serum uric acid (UA) is associated with development of micro-albuminuria in the general population. Methodology/Principal Findings: We conducted a community-based prospective cohort study. A total of 1862 subjects from southern Taiwan, all older than 40 years, were screened and 993 of these participants without micro-albuminuria were followed for 4 years. Urinary albumin-to-creatinine ratio was measured two times per year. A multiple linear regression model indicated that serum UA was independently associated with ln(ACR) after adjustment for 8 factors (age, sex, and 6 metabolic metrics) (β = 0.194, p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0061450

DOI: 10.1371/journal.pone.0061450

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