The SEPS1 G-105A Polymorphism Is Associated with Risk of Spontaneous Preterm Birth in a Chinese Population

Yan Wang, Xiao Yang, Yong Zheng, Zhi-Hao Wu, Xiao-Ai Zhang, Qiu-Ping Li, Xi-Yu He, Chun-Zhi Wang and Zhi-Chun Feng

PLOS ONE, 2013, vol. 8, issue 6, 1-7

Abstract: Inflammation plays an important role in the etiology and pathophysiology of spontaneous preterm birth (SPTB), and selenoprotein S (SEPS1) is involved in regulating the inflammatory response. Recently the G-105A promoter polymorphism in SEPS1 was shown to increase pro-inflammatory cytokine expression. We examined whether this functional polymorphism was related to the risk of SPTB in a Chinese population. We also examined the impact of premature rupture of membranes (PROM) on susceptibility to SPTB. The SEPS1 G-105A polymorphism was genotyped in 569 preterm singleton neonates and 673 term neonates by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. χ2 tests and logistic regression analyses were used to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs). We observed that, compared with the GG genotype, –105A positive genotypes (GA + AA genotypes) were associated with significantly increased susceptibility to SPTB (adjusted OR, 1.87; 95% CI, 1.36–2.57; P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0065657

DOI: 10.1371/journal.pone.0065657

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