Deferasirox and Vitamin D Improves Overall Survival in Elderly Patients with Acute Myeloid Leukemia after Demethylating Agents Failure

Etienne Paubelle, Florence Zylbersztejn, Sawsaneh Alkhaeir, Felipe Suarez, Céline Callens, Michaël Dussiot, Françoise Isnard, Marie-Thérèse Rubio, Gandhi Damaj, Norbert-Claude Gorin, Jean-Pierre Marolleau, Renato C Monteiro, Ivan C Moura and Olivier Hermine

PLOS ONE, 2013, vol. 8, issue 6, 1-4

Abstract: The prognosis of acute myeloid leukemia (AML) in elderly (≥65 years) patients is poor and treatment remains non-consensual especially for those who are not eligible for intensive therapies. Our group has shown that in vitro the iron chelator deferasirox (DFX) synergizes with vitamin D (VD) to promote monocyte differentiation in primary AML cells. Herein, we present results from a retrospective case-control study in which the association of DFX (1–2 g/d) and 25-hydroxycholecalciferol (100,000 IU/week) (DFX/VD) was proposed to patients following demethylating agents failure. Median survival of patients treated with DFX/VD combination (n = 17) was significantly increased in comparison with matched patients receiving best supportive care (BSC) alone (n = 13) (10.4 versus 4 months respectively). In addition, the only factor associated to an increased overall survival in DFX/VD-treated patients was serum VD levels. We conclude that DFX/VD treatment correlated with increased overall survival of AML patients in this retrospective cohort of elderly patients.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0065998

DOI: 10.1371/journal.pone.0065998

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