Increased Risk of Developing Digestive Tract Cancer in Subjects Carrying the PLCE1 rs2274223 A>G Polymorphism: Evidence from a Meta-Analysis

Xunlei Zhang, Yangmei Zhang, Dongying Gu, Chunxiang Cao, Qi Zhang, Zhi Xu, Yongling Gong, Jinfei Chen and Cuiju Tang

PLOS ONE, 2013, vol. 8, issue 10, 1-9

Abstract: Background: To date, the association between phospholipase C epsilon 1 (PLCE1) rs2274223 A>G and risk of digestive tract cancer (DTC) remains inconclusive. To derive a more precise estimation of the association, we conducted a meta-analysis on all eligible case–control studies involving 8281 cases and 10,532 controls. Methods: A comprehensive search was conducted to identify all eligible studies of PLCE1 rs2274223 polymorphism and digestive tract cancer risk. The pooled odds ratio (OR) and the 95% confidence interval (95% CI) were calculated using a fixed or random effect model. Heterogeneity, publication bias, and sensitivity analysis were also explored. Results: Overall, the PLCE1 rs2274223 A>G polymorphism was associated with risk of DTC in all genetic models (GA vs. AA: OR = 1.21, 95% CI = 1.14–1.29, P G polymorphism was significantly associated with increased risk of DTC, especially among Asian populations. Due to some minor limitations, our findings should be confirmed in further studies.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0076425

DOI: 10.1371/journal.pone.0076425

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