GSTM1 and GSTT1 Null Polymorphisms and Childhood Acute Leukemia Risk: Evidence from 26 Case-Control Studies

Qiuqin Tang, Jing Li, Simin Zhang, Beilei Yuan, Hong Sun, Di Wu, Chuncheng Lu, Wei Wu, Yankai Xia, Hongjuan Ding, Lingqing Hu, Daozhen Chen, Jiahao Sha and Xinru Wang

PLOS ONE, 2013, vol. 8, issue 10, 1-

Abstract: Several molecular epidemiological studies have been conducted to examine the association between glutathione S-transferase mu-1 (GSTM1) and glutathione S-transferase theta-1 (GSTT1) null polymorphisms and childhood acute leukemia; however, the conclusions remain controversial. We performed an extensive meta-analysis on 26 published case-control studies with a total of 3252 cases and 5024 controls. Crude odds ratios (ORs) with 95% confidence interval were used to assess the strength of association between childhood acute leukemia risk and polymorphisms of GSTM1 and GSTT1. With respect to GSTM1 polymorphism, significantly increased risk of childhood acute leukemia was observed in the overall analysis (OR = 1.30; 95%CI, 1.11-1.51). Furthermore, a stratification analysis showed that the risk of GSTM1 polymorphism are associated with childhood acute leukemia in group of Asians (OR = 1.94; 95%CI, 1.53-2.46), Blacks (OR = 1.76; 95%CI, 1.07-2.91), ALL (OR = 1.33; 95%CI, 1.13-1.58), ‘

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0078810

DOI: 10.1371/journal.pone.0078810

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