Depression in Atrial Fibrillation in the General Population

Renate B Schnabel, Matthias Michal, Sandra Wilde, Jörg Wiltink, Philipp S Wild, Christoph R Sinning, Edith Lubos, Francisco M Ojeda, Tanja Zeller, Thomas Munzel, Stefan Blankenberg and Manfred E Beutel

PLOS ONE, 2013, vol. 8, issue 12, 1-6

Abstract: Background: Initial evidence suggests that depressive symptoms are more frequent in patients with atrial fibrillation. Data from the general population are limited. Methods and Results: In 10,000 individuals (mean age 56±11 years, 49.4% women) of the population-based Gutenberg Health Study we assessed depression by the Patient Health Questionnaire (PHQ-9) and a history of depression in relation to manifest atrial fibrillation (n = 309 cases). The median (25th/75th percentile) PHQ-9 score of depressive symptoms was 4 (2/6) in atrial fibrillation individuals versus 3 (2/6) individuals without atrial fibrillation, . Multivariable regression analyses of the severity of depressive symptoms in relation to atrial fibrillation in cardiovascular risk factor adjusted models revealed a relation of PHQ-9 values and atrial fibrillation (odds ratio (OR) 1.04, 95% confidence interval (CI) 1.01–1.08; P = 0.023). The association was stronger for the somatic symptom dimension of depression (OR 1.08, 95% CI 1.02–1.15; P = 0.0085) than for cognitive symptoms (OR 1.05, 95% CI 0.98–1.11; P = 0.15). Results did not change markedly after additional adjustment for heart failure, partnership status or the inflammatory biomarker C-reactive protein. Both, self-reported physical health status, very good/good versus fair/bad, (OR 0.54, 95% CI 0.41–0.70; P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0079109

DOI: 10.1371/journal.pone.0079109

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