Elevated Alanine Aminotransferase Is Strongly Associated with Incident Metabolic Syndrome: A Meta-Analysis of Prospective Studies

Zhengtao Liu, Shuping Que, Huaijun Ning, Linlin Wang and Tao Peng

PLOS ONE, 2013, vol. 8, issue 12, 1-11

Abstract: Background: The incidence of metabolic syndrome (MetS) is rapidly increasing worldwide and associated with alanine aminotransferase (ALT) activity. However, the impact of ALT activity on MetS incidence is inconsistent in published literature. We therefore estimated the association between elevated ALT activity and incident MetS through a meta-analysis of prospective cohort studies. Methods/Principal Findings: All published prospective cohort studies on the association between elevated ALT activity and incident MetS were retrieved from Pubmed, Embase, and the Institute for Scientific Information (ISI). In all, seven prospective cohort studies, with 31545 participants and 2873 cases of incident MetS were recruited. If there was insignificant heterogeneity (P-value>0.05 and I2

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0080596

DOI: 10.1371/journal.pone.0080596

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