Vitamin D Status during Pregnancy and the Risk of Subsequent Postpartum Depression: A Case-Control Study

Nina O Nielsen, Marin Strøm, Heather A Boyd, Elisabeth W Andersen, Jan Wohlfahrt, Marika Lundqvist, Arieh Cohen, David M Hougaard and Mads Melbye

PLOS ONE, 2013, vol. 8, issue 11, 1-8

Abstract: Epidemiological studies have provided evidence of an association between vitamin D insufficiency and depression and other mood disorders, and a role for vitamin D in various brain functions has been suggested. We hypothesized that low vitamin D status during pregnancy might increase the risk of postpartum depression (PPD). The objective of the study was thus to determine whether low vitamin D status during pregnancy was associated with postpartum depression. In a case-control study nested in the Danish National Birth Cohort, we measured late pregnancy serum concentrations of 25[OH]D3 in 605 women with PPD and 875 controls. Odds ratios [OR) for PPD were calculated for six levels of 25[OH]D3. Overall, we found no association between vitamin D concentrations and risk of PPD (p = 0.08). Compared with women with vitamin D concentrations between 50 and 79 nmol/L, the adjusted odds ratios for PPD were 1.35 (95% CI: 0.64; 2.85), 0.83 (CI: 0.50; 1.39) and 1.13 (CI: 0.84; 1.51) among women with vitamin D concentrations

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0080686

DOI: 10.1371/journal.pone.0080686

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