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Structural Insights into RbmA, a Biofilm Scaffolding Protein of V. Cholerae

Manuel Maestre-Reyna, Wen-Jin Wu and Andrew H-J Wang

PLOS ONE, 2013, vol. 8, issue 12, 1-

Abstract: V. cholerae can form sessile biofilms associated with abiotic surfaces, cyanobacteria, zoo-plankton, mollusks, or crustaceans. Along with the vibrio polysaccharide, secreted proteins of the rbm gene cluster are key to the biofilm ultrastructure. Here we provide a thorough structural characterization of RbmA, a protein involved in mediating cell-cell and cell-biofilm contacts. We correlate our structural findings with initial ligand specificity screening results, NMR protein-ligand interaction analysis, and complement our results with a full biocomputational study.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0082458

DOI: 10.1371/journal.pone.0082458

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