Heritable Influence of DBH on Adrenergic and Renal Function: Twin and Disease Studies

Dalal N Pasha, Jason T Davis, Fangwen Rao, Yuqing Chen, Gen Wen, Maple M Fung, Manjula Mahata, Kuixing Zhang, Danuta Trzebinska, Maja Mustapic, C Makena Hightower, Michael S Lipkowitz, Ming Ji, Michael G Ziegler, Caroline M Nievergelt and Daniel T O'Connor

PLOS ONE, 2013, vol. 8, issue 12, 1-10

Abstract: Background: Elevated sympathetic activity is associated with kidney dysfunction. Here we used twin pairs to probe heritability of GFR and its genetic covariance with other traits. Methods: We evaluated renal and adrenergic phenotypes in twins. GFR was estimated by CKD-EPI algorithm. Heritability and genetic covariance of eGFR and associated risk traits were estimated by variance-components. Meta-analysis probed reproducibility of DBH genetic effects. Effect of DBH genetic variation on renal disease was tested in the NIDDK-AASK cohort. Results: Norepinephrine secretion rose across eGFR tertiles while eGFR fell (p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0082956

DOI: 10.1371/journal.pone.0082956

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