Utilizing Twins as Controls for Non-Twin Case-Materials in Genome Wide Association Studies

Andrea Ganna, Alfredo Ortega-Alonso, Aki Havulinna, Veikko Salomaa, Jaakko Kaprio, Nancy L Pedersen, Patrick F Sullivan, Erik Ingelsson, Christina M Hultman and Patrik K E Magnusson

PLOS ONE, 2013, vol. 8, issue 12, 1-

Abstract: Twin registries around the globe have collected DNA samples from large numbers of monozygotic and dizygotic twins. The twin sample collections are frequently used as controls in disease-specific studies together with non-twins. This approach is unbiased under the hypothesis that twins and singletons are comparable in terms of allele frequencies; i.e. there are no genetic variants associated with being a twin per se. To test this hypothesis we performed a genome-wide association study comparing the allele frequency of 572,352 single nucleotide polymorphisms (SNPs) in 1,413 monozygotic (MZ) and 5,451 dizygotic (DZ) twins with 3,720 healthy singletons. Twins and singletons have been genotyped using the same platform. SNPs showing association with being a twin at P-value

Date: 2013
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083101 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 83101&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0083101

DOI: 10.1371/journal.pone.0083101

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().