Clozapine Prescribing in a Canadian Outpatient Population

Silvia Alessi-Severini, Josee-Anne Le Dorze, David Nguyen, Patricia Honcharik and Michael Eleff

PLOS ONE, 2013, vol. 8, issue 12, 1-

Abstract: Objective: Description of demographics of an outpatient population of clozapine users. Methods: Retrospective chart review study of an urban population diagnosed with schizophrenia. Assessment of therapeutic histories in relation to clinical practice guidelines. Results: Seventy-seven of the 467 patients were on clozapine therapy. Average patients’ age was 39.4 ± 11.8 years) and 68% were males. The majority of patients (68%) had tried 3 or more antipsychotics before switching to clozapine, 21% had tried two and 11% had tried one. Median length of therapy prior to clozapine initiation was 8.9 years in males and 7.7 years in females. Conclusion: Until 2010, the use of clozapine was often delayed and more than 2 antipsychotic medications were tried for relatively long periods of time before patients were switched to this effective agent.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0083539

DOI: 10.1371/journal.pone.0083539

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