Effect of C-Terminal Residues of Aβ on Copper Binding Affinity, Structural Conversion and Aggregation

Shu-Hsiang Huang, Shyue-Chu Ke, Ta-Hsin Lin, Hsin-Bin Huang and Yi-Cheng Chen

PLOS ONE, 2014, vol. 9, issue 3, 1-10

Abstract: Many properties of Aβ such as toxicity, aggregation and ROS formation are modulated by Cu2+. Previously, the coordination configuration and interaction of Cu2+ with the Aβ N-terminus has been extensively studied. However, the effect of Aβ C-terminal residues on related properties is still unclear. In the present study, several C-terminus-truncated Aβ peptides, including Aβ1-40, Aβ1-35, Aβ1-29, Aβ1-24 and Aβ1-16, were synthesized to characterize the effect of Aβ C-terminal residues on Cu2+ binding affinity, structure, aggregation ability and ROS formation. Results show that the Aβ C-terminal residues have effect on Cu2+ binding affinity, aggregation ability and inhibitory ability of ROS formation. Compared to the key residues responsible for Aβ aggregation and structure in the absence of Cu2+, it is more likely that residues 36–40, rather than residues 17–21 and 30–35, play a key role on the related properties of Aβ in the presence of Cu2+.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0090385

DOI: 10.1371/journal.pone.0090385

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