Predictors of Two Months Culture Conversion in Multidrug-Resistant Tuberculosis: Findings from a Retrospective Cohort Study

Anila Basit, Nafees Ahmad, Amer Hayat Khan, Arshad Javaid, Syed Azhar Syed Sulaiman, Afsar Khan Afridi, Azreen Syazril Adnan, Israr ul Haq, Syed Saleem Shah, Ahmed Ahadi and Izaz Ahmad

PLOS ONE, 2014, vol. 9, issue 4, 1-6

Abstract: Background: Various studies have reported culture conversion at two months as a predictor of successful treatment outcome in multidrug-resistant tuberculosis (MDR-TB). Objectives: The present study was conducted with the aim to evaluate the rate and predictors of culture conversion at two months in MDR-TB patients. Methods: All confirmed pulmonary MDR-TB patients enrolled for treatment at Lady Reading Hospital Peshawar, Pakistan from 1 January to 31 December 2012 and met the inclusion criteria were reviewed retrospectively. Rate and predictors of culture conversion at two months were evaluated. Results: Eighty seven (53.4%) out of 163 patients achieved culture conversion at two months. In a multivariate analysis lung cavitation at baseline chest X-ray (P = 0.006, OR = 0.349), resistance to ofloxacin (P = 0.041, OR = 0.193) and streptomycin (P = 0.017, OR = 0.295) had statistically significant (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0093206

DOI: 10.1371/journal.pone.0093206

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