L-Type Ca2+ Channel Sparklets Revealed by TIRF Microscopy in Mouse Urinary Bladder Smooth Muscle

Peter Sidaway and Noriyoshi Teramoto

PLOS ONE, 2014, vol. 9, issue 4, 1-11

Abstract: Calcium is a ubiquitous second messenger in urinary bladder smooth muscle (UBSM). In this study, small discrete elevations of intracellular Ca2+, referred to as Ca2+ sparklets have been detected in an intact detrusor smooth muscle electrical syncytium using a TIRF microscopy Ca2+ imaging approach. Sparklets were virtually abolished by the removal of extracellular Ca2+ (0.035±0.01 vs. 0.23±0.07 Hz/mm2; P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0093803

DOI: 10.1371/journal.pone.0093803

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