Cardiac High-Energy Phosphate Metabolism Alters with Age as Studied in 196 Healthy Males with the Help of 31-Phosphorus 2-Dimensional Chemical Shift Imaging

Regina Esterhammer, Gert Klug, Christian Wolf, Agnes Mayr, Sebastian Reinstadler, Hans-Josef Feistritzer, Bernhard Metzler and Michael F H Schocke

PLOS ONE, 2014, vol. 9, issue 6, 1-9

Abstract: Recently published studies have elucidated alterations of mitochondrial oxidative metabolism during ageing. The intention of the present study was to evaluate the impact of ageing on cardiac high-energy phosphate metabolism and cardiac function in healthy humans. 31-phosphorus 2-dimensional chemical shift imaging (31P 2D CSI) and echocardiography were performed in 196 healthy male volunteers divided into groups of 20 to 40 years (I, n = 43), 40 to 60 years (II, n = 123) and >60 years (III, n = 27) of age. Left ventricular PCr/β-ATP ratio, myocardial mass (MM), ejection fraction and E/A ratio were assessed. Mean PCr/β-ATP ratios were significantly different among the three groups of volunteers (I, 2.10±0.37; II, 1.77±0.37; III, 1.45±0.28; all p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0097368

DOI: 10.1371/journal.pone.0097368

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