Synaptonemal Complex Protein 3 Is a Prognostic Marker in Cervical Cancer

Hanbyoul Cho, Kyung Hee Noh, Joon-Yong Chung, Mikiko Takikita, Eun Joo Chung, Bo Wook Kim, Stephen M Hewitt, Tae Woo Kim and Jae-Hoon Kim

PLOS ONE, 2014, vol. 9, issue 6, 1-12

Abstract: Synaptonemal complex protein 3 (SCP3), a member of Cor1 family, is up-regulated in various cancer cells; however, its oncogenic potential and clinical significance has not yet been characterized. In the present study, we investigated the oncogenic role of SCP3 and its relationship with phosphorylated AKT (pAKT) in cervical neoplasias. The functional role of SCP3 expression was investigated by overexpression or knockdown of SCP3 in murine cell line NIH3T3 and human cervical cancer cell lines CUMC6, SiHa, CaSki, and HeLa both in vitro and in vivo. Furthermore, we examined SCP3 expression in tumor specimens from 181 cervical cancer and 400 cervical intraepithelial neoplasia (CIN) patients by immunohistochemistry and analyzed the correlation between SCP3 expression and clinicopathologic factors or survival. Overexpression of SCP3 promoted AKT-mediated tumorigenesis both in vitro and in vivo. Functional studies using NIH3T3 cells demonstrated that the C-terminal region of human SCP3 is important for AKT activation and its oncogenic potential. High expression of SCP3 was significantly associated with tumor stage (P = 0.002) and tumor grade (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0098712

DOI: 10.1371/journal.pone.0098712

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