Impact of Sleep-Disordered Breathing on Heart Rate Turbulence in Heart Failure Patients

Akiomi Yoshihisa, Satoshi Suzuki, Mai Takiguchi, Takeshi Shimizu, Satoshi Abe, Takamasa Sato, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh and Yasuchika Takeishi

PLOS ONE, 2014, vol. 9, issue 6, 1-6

Abstract: Background: Sleep-disordered breathing (SDB) is associated with adverse outcomes in patients with chronic heart failure (CHF). Additionally, heart rate turbulence (HRT) reflects changes in the sinus cycle length of baroreceptor in response to hemodynamic fluctuations after ventricular premature beat. Recent studies have suggested that HRT as a marker of vagal activity has a predictive value of poor prognosis in CHF patients. However, little is known about the relationship between SDB and HRT in CHF patients. Methods and Results: In this study, 75 patients with CHF were enrolled. We simultaneously performed Holter ECG during a 24-hr period and portable sleep monitoring at nighttime, and determined the respiratory disturbance index (RDI), HRT (turbulence onset (TO) and turbulence slope (TS)) during that 24-hr period. These patients were divided into two groups based on the presence of severe SDB: Group A (RDI≥30, n = 17) and Group B (RDI

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0101307

DOI: 10.1371/journal.pone.0101307

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