Neurocognitive Function in HIV-Infected Patients: Comparison of Two Methods to Define Impairment

Alejandro Arenas-Pinto, Alan Winston, Wolfgang Stöhr, John Day, Rebecca Wiggins, Say Pheng Quah, Jonathan Ainsworth, Sue Fleck, David Dunn, Alex Accoroni, Nicholas I Paton and for the PIVOT Trial Team

PLOS ONE, 2014, vol. 9, issue 7, 1-7

Abstract: Objective: To compare two definitions of neurocognitive impairment (NCI) in a large clinical trial of effectively-treated HIV-infected adults at baseline. Methods: Hopkins Verbal Learning test-Revised (HVLT-R), Colour Trail (CTT) and Grooved Pegboard (GPT) tests were applied exploring five cognitive domains. Raw scores were transformed into Z-scores and NCI defined as summary NPZ-5 score one standard deviation below the mean of the normative dataset (i.e.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0103498

DOI: 10.1371/journal.pone.0103498

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