ATO/ATRA/Anthracycline-Chemotherapy Sequential Consolidation Achieves Long-Term Efficacy in Primary Acute Promyelocytic Leukemia

Zi-Jie Long, Yuan Hu, Xu-Dong Li, Yi He, Ruo-Zhi Xiao, Zhi-Gang Fang, Dong-Ning Wang, Jia-Jun Liu, Jin-Song Yan, Ren-Wei Huang, Dong-Jun Lin and Quentin Liu

PLOS ONE, 2014, vol. 9, issue 8, 1-8

Abstract: The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3, ATO) has been effective in obtaining high clinical complete remission (CR) rates in acute promyelocytic leukemia (APL), but the long-term efficacy and safety among newly diagnosed APL patients are unclear. In this retrospective study, total 45 newly diagnosed APL patients received ATRA/chemotherapy combination regimen to induce remission. Among them, 43 patients (95.6%) achieved complete remission (CR) after induction therapy, followed by ATO/ATRA/anthracycline-based chemotherapy sequential consolidation treatment with a median follow-up of 55 months. In these patients, the estimated overall survival (OS) and the relapse-free survival (RFS) were 94.4%±3.9% and 94.6±3.7%, respectively. The toxicity profile was mild and reversible. No secondary carcinoma was observed. These results demonstrated the high efficacy and minimal toxicity of ATO/ATRA/anthracycline-based chemotherapy sequential consolidation treatment for newly diagnosed APL in long-term follow-up, suggesting a potential frontline therapy for APL.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0104610

DOI: 10.1371/journal.pone.0104610

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