The Gait Disorder in Downbeat Nystagmus Syndrome

Roman Schniepp, Max Wuehr, Sabrina Huth, Cauchy Pradhan, Cornelia Schlick, Thomas Brandt and Klaus Jahn

PLOS ONE, 2014, vol. 9, issue 8, 1-7

Abstract: Background: Downbeat nystagmus (DBN) is a common form of acquired fixation nystagmus with key symptoms of oscillopsia and gait disturbance. Gait disturbance could be a result of impaired visual feedback due to the involuntary ocular oscillations. Alternatively, a malfunction of cerebellar locomotor control might be involved, since DBN is considered a vestibulocerebellar disorder. Methods: Investigation of walking in 50 DBN patients (age 72±11 years, 23 females) and 50 healthy controls (HS) (age 70±11 years, 23 females) using a pressure sensitive carpet (GAITRite). The patient cohort comprised subjects with only ocular motor signs (DBN) and subjects with an additional limb ataxia (DBNCA). Gait investigation comprised different walking speeds and walking with eyes closed. Results: In DBN, gait velocity was reduced (p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0105463

DOI: 10.1371/journal.pone.0105463

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