Homocysteine as a Risk Factor for Hypertension: A 2-Year Follow-Up Study

Yixuan Wang, Shuohua Chen, Tao Yao, DongQing Li, YanXiu Wang, YuQing Li, ShouLing Wu and Jun Cai

PLOS ONE, 2014, vol. 9, issue 10, 1-8

Abstract: Homocysteine (Hcy) is regarded as a risk factor for hypertension, but research on the causal relationship between Hcy and hypertension is limited. In the present study, we prospectively tracked the blood pressure progression of a normotensive population with different Hcy levels over a 2-year period. The incidence of hypertension with increasing Hcy quartiles produced an approximately U-shaped curve, with significance in males. Compared with the third quartile, the risk of hypertension in the first and second quartiles was increased by 1.55 (95% confidence interval [CI] 1.154–2.081) fold and 1.501 (95% CI 1.119–2.013) fold, respectively, with the increase being more significant in males. In conclusion, Hcy is related to hypertension incidence with the results approximating an U-shaped curve. Low Hcy levels might also increase the risk of hypertension.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0108223

DOI: 10.1371/journal.pone.0108223

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