The Association of HMGB1 Expression with Clinicopathological Significance and Prognosis in Hepatocellular Carcinoma: A Meta-Analysis and Literature Review

Lu Zhang, Jianjun Han, Huiyong Wu, Xiaohong Liang, Jianxin Zhang, Jian Li, Li Xie, Yinfa Xie, Xiugui Sheng and Jinming Yu

PLOS ONE, 2014, vol. 9, issue 10, 1-8

Abstract: Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer, and it is the second most common cancer-related mortality globally. The prognostic value of high mobility group box 1 (HMGB1) remains controversial. The purpose of this study is to conduct a meta-analysis and literature review to evaluate the association of HMGB1 expression with the prognosis of patients with HCC. Methods: A detailed literature search was made in Medline, Google Scholar and others for related research publications. The data were extracted and assessed by two reviewers independently. Analysis of pooled data were performed, Hazard Ratio (HR) and mean difference with corresponding confidence intervals (CIs) were calculated and summarized respectively. Results: 10 relevant articles were included for this meta-analysis study. HMGB1 mRNA levels in HCC were significantly higher than those in normal (p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0110626

DOI: 10.1371/journal.pone.0110626

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