Hyperhomocysteinemia in Patients with Polypoidal Choroidal Vasculopathy: A Case Control Study

Hui-Chen Cheng, Jorn-Hon Liu, Shui-Mei Lee and Po-Kang Lin

PLOS ONE, 2014, vol. 9, issue 10, 1-6

Abstract: Purpose: To determine whether elevated plasma homocysteine and serum high sensitivity C-reactive protein (hsCRP) levels, two established risk factors of vascular diseases, are associated with polypoidal choroidal vasculopathy (PCV). Design: Retrospective case-control study. Methods: One hundred and nineteen consecutive patients with PCV and 119 matched controls were enrolled in a tertiary hospital from September 2008 to June 2013. Plasma homocysteine and serum hsCRP levels were measured. Associations among plasma homocysteine, serum hsCRP levels and PCV were further evaluated using multivariable logistic regression analysis. Results: The median plasma homocysteine level was significantly higher in patients with PCV than in the controls (12.20 µmol/L vs. 9.80 µmol/L, p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0110818

DOI: 10.1371/journal.pone.0110818

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